An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

Voltage-gated Na(+) channels are composed of pore-forming α and auxiliary β subunits. The majority of Na(+) channels in the heart contain tetrodotoxin (TTX)-insensitive Na(v)1.5 α subunits, but TTX-sensitive brain-type Na(+) channel α subunits are present and functionally important in the transverse...

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Bibliographic Details
Main Authors: Maier, Sebastian K. G., Westenbroek, Ruth E., Yamanushi, T. T., Dobrzynski, H., Boyett, Mark R., Catterall, William A., Scheuer, Todd
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC152323/
https://ncbi.nlm.nih.gov/pubmed/12631690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2627986100
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