Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

The majority of Na(+) channels in the heart are composed of the tetrodotoxin (TTX)-resistant (K(D), 2–6 μm) Na(v)1.5 isoform; however, recently it has been shown that TTX-sensitive (K(D), 1–10 nm) neuronal Na(+) channel isoforms (Na(v)1.1, Na(v)1.3 and Na(v)1.6) are also present and functionally imp...

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Autors principals: Lei, Ming, Jones, Sandra A, Liu, Jie, Lancaster, Matthew K, Fung, Simon S-M, Dobrzynski, Halina, Camelliti, Patrizia, Maier, Sebastian K G, Noble, Denis, Boyett, Mark R
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665172/
https://ncbi.nlm.nih.gov/pubmed/15254155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.068643
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