Translational Compensation of a Frameshift Mutation Affecting Herpes Simplex Virus Thymidine Kinase Is Sufficient To Permit Reactivation from Latency

Herpes simplex virus thymidine kinase is important for reactivation of virus from its latent state and is a target for the antiviral drug acyclovir. Most acyclovir-resistant isolates have mutations in the thymidine kinase gene; however, how these mutations confer clinically relevant resistance is un...

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Detalhes bibliográficos
Main Authors: Griffiths, Anthony, Chen, Shun-Hua, Horsburgh, Brian C., Coen, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152167/
https://ncbi.nlm.nih.gov/pubmed/12663777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4703-4709.2003
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