Mutation Spectra of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants

To examine whether the exonuclease activity intrinsic to the polymerase (Pol) of herpes simplex virus type 1 can influence the mutational spectra, we applied the denaturing gradient gel electrophoresis (DGGE) system combined with sequencing to characterize thymidine kinase mutants isolated from both...

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Bibliographic Details
Main Authors: Lu, Qiaosheng, Hwang, Ying T., Hwang, Charles B. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC137007/
https://ncbi.nlm.nih.gov/pubmed/11992012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.11.5822-5828.2002
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