Effects of Exonuclease Activity and Nucleotide Selectivity of the Herpes Simplex Virus DNA Polymerase on the Fidelity of DNA Replication In Vivo

A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated by wild-type herpes simplex virus type 1 (HSV-1) strain KOS and its polymerase (Pol) mutant derivatives PAA(r)5, Y7, and YD12. The pHOS1 shuttle plasmid, which contained the SupF mutagenesis marker g...

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Bibliographische Detailangaben
Hauptverfasser: Hwang, Ying T., Liu, Bu-Yuan, Hong, Chi-Yuan, Shillitoe, Edward J., Hwang, Charles B. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112588/
https://ncbi.nlm.nih.gov/pubmed/10364279
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