Effects of Exonuclease Activity and Nucleotide Selectivity of the Herpes Simplex Virus DNA Polymerase on the Fidelity of DNA Replication In Vivo

A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated by wild-type herpes simplex virus type 1 (HSV-1) strain KOS and its polymerase (Pol) mutant derivatives PAA(r)5, Y7, and YD12. The pHOS1 shuttle plasmid, which contained the SupF mutagenesis marker g...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Hwang, Ying T., Liu, Bu-Yuan, Hong, Chi-Yuan, Shillitoe, Edward J., Hwang, Charles B. C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364279/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5326-5332.1999
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