Translational Compensation of a Frameshift Mutation Affecting Herpes Simplex Virus Thymidine Kinase Is Sufficient To Permit Reactivation from Latency

Herpes simplex virus thymidine kinase is important for reactivation of virus from its latent state and is a target for the antiviral drug acyclovir. Most acyclovir-resistant isolates have mutations in the thymidine kinase gene; however, how these mutations confer clinically relevant resistance is un...

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Pubblicato in:	J Virol
Autori principali:	Griffiths, Anthony, Chen, Shun-Hua, Horsburgh, Brian C., Coen, Donald M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.4703-4709.2003
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