Translational Compensation of a Frameshift Mutation Affecting Herpes Simplex Virus Thymidine Kinase Is Sufficient To Permit Reactivation from Latency

Herpes simplex virus thymidine kinase is important for reactivation of virus from its latent state and is a target for the antiviral drug acyclovir. Most acyclovir-resistant isolates have mutations in the thymidine kinase gene; however, how these mutations confer clinically relevant resistance is un...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Griffiths, Anthony, Chen, Shun-Hua, Horsburgh, Brian C., Coen, Donald M.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2003
Gaiak:	Vaccines and Antiviral Agents
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.4703-4709.2003
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