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Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis
We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsor...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151351/ https://ncbi.nlm.nih.gov/pubmed/12591960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0335642100 |
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