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Inhibitor design by wrapping packing defects in HIV-1 proteins
Two viral proteins, HIV-1 protease and HIV-1 integrase, have been targeted for inhibitor design to prevent assembly and maturation of HIV-1 virions. The enzymatic mechanism of these proteins involves side-chain groups that serve as general acids or bases. Furthermore, catalytic activity requires tha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC511032/ https://ncbi.nlm.nih.gov/pubmed/15289598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404641101 |
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