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Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis

We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsor...

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Autors principals: Fernández, Ariel, Berry, R. Stephen
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC151351/
https://ncbi.nlm.nih.gov/pubmed/12591960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0335642100
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