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Extent of hydrogen-bond protection in folded proteins: a constraint on packing architectures.

Progressive structuring and ultimately exclusion of water by hydrophobes surrounding backbone hydrogen bonds turn the latter into guiding factors of protein folding. Here we demonstrate that an arrangement of five hydrophobes yields an optimal hydrogen-bond stabilization. This motif is shown to be n...

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Detalhes bibliográficos
Main Authors: Fernández, Ariel, Berry, R Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302333/
https://ncbi.nlm.nih.gov/pubmed/12414681
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