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Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP

Our hypothesis is that oxytocin (OT) causes natriuresis by activation of renal NO synthase that releases NO followed by cGMP that mediates the natriuresis. To test this hypothesis, an inhibitor of NO synthase, l-nitroarginine methyl ester (NAME), was injected into male rats. Blockade of NO release b...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Soares, T. J., Coimbra, T. M., Martins, A. R., Pereira, A. G. F., Carnio, E. C., Branco, L. G. S., Albuquerque-Araujo, W. I. C., de Nucci, G., Favaretto, A. L. V., Gutkowska, J., McCann, S. M., Antunes-Rodrigues, J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15130/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874809/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.278
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