PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

The phosphatase PTEN regulates growth, adhesion, and apoptosis, among many other cell processes. To investigate its role during mouse mammary gland development, we generated MK-PTEN, a transgenic mouse model in which human PTEN is overexpressed in ductal and alveolar mammary epithelium during pubert...

ver descrição completa

Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Dupont, Joëlle, Renou, Jean Pierre, Shani, Moshe, Hennighausen, Lothar, LeRoith, Derek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151121/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12235113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13829
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!