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PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
The phosphatase PTEN regulates growth, adhesion, and apoptosis, among many other cell processes. To investigate its role during mouse mammary gland development, we generated MK-PTEN, a transgenic mouse model in which human PTEN is overexpressed in ductal and alveolar mammary epithelium during pubert...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2002
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151121/ https://ncbi.nlm.nih.gov/pubmed/12235113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13829 |
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