PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

The phosphatase PTEN regulates growth, adhesion, and apoptosis, among many other cell processes. To investigate its role during mouse mammary gland development, we generated MK-PTEN, a transgenic mouse model in which human PTEN is overexpressed in ductal and alveolar mammary epithelium during pubert...

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Pubblicato in:	J Clin Invest
Autori principali:	Dupont, Joëlle, Renou, Jean Pierre, Shani, Moshe, Hennighausen, Lothar, LeRoith, Derek
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151121/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12235113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13829
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