PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

The phosphatase PTEN regulates growth, adhesion, and apoptosis, among many other cell processes. To investigate its role during mouse mammary gland development, we generated MK-PTEN, a transgenic mouse model in which human PTEN is overexpressed in ductal and alveolar mammary epithelium during pubert...

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Bibliographic Details
Main Authors: Dupont, Joëlle, Renou, Jean Pierre, Shani, Moshe, Hennighausen, Lothar, LeRoith, Derek
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151121/
https://ncbi.nlm.nih.gov/pubmed/12235113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13829
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