SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Míreanna Comhchosúla

• Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
  le: Chen, Guoxun, et al.
  Foilsithe: (2004)
• SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
  le: Matsuda, Morihiro, et al.
  Foilsithe: (2001)
• Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
  le: Shimano, H, et al.
  Foilsithe: (1996)
• Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
  le: Shimano, H, et al.
  Foilsithe: (1997)
• Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
  le: Horton, J D, et al.
  Foilsithe: (1998)