Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain

Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral infarct volumes in mice following transient middle cerebral artery occlusion, even when given 3 hours a...

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Bibliografische gegevens
Hoofdauteurs: Pinsky, David J., Broekman, M. Johan, Peschon, Jacques J., Stocking, Kim L., Fujita, Tomoyuki, Ramasamy, Ravichandran, Connolly, E. Sander, Huang, Judy, Kiss, Szilard, Zhang, Yuan, Choudhri, Tanvir F., McTaggart, Ryan A., Liao, Hui, Drosopoulos, Joan H.F., Price, Virginia L., Marcus, Aaron J., Maliszewski, Charles R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2002
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150939/
https://ncbi.nlm.nih.gov/pubmed/11956240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI10649
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