Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species. Although the antioxidant ascorbic acid (AA) or vitamin C does not penetrate the blood–brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport. W...

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Detalles Bibliográficos
Autores principales: Huang, Judy, Agus, David B., Winfree, Christopher J., Kiss, Szilard, Mack, William J., McTaggart, Ryan A., Choudhri, Tanvir F., Kim, Louis J, Mocco, J, Pinsky, David J., Fox, William D., Israel, Robert J., Boyd, Thomas A., Golde, David W., Connolly, E. Sander
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC58796/
https://ncbi.nlm.nih.gov/pubmed/11573006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171325998
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