Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species. Although the antioxidant ascorbic acid (AA) or vitamin C does not penetrate the blood–brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport. W...

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Bibliographic Details
Main Authors: Huang, Judy, Agus, David B., Winfree, Christopher J., Kiss, Szilard, Mack, William J., McTaggart, Ryan A., Choudhri, Tanvir F., Kim, Louis J, Mocco, J, Pinsky, David J., Fox, William D., Israel, Robert J., Boyd, Thomas A., Golde, David W., Connolly, E. Sander
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC58796/
https://ncbi.nlm.nih.gov/pubmed/11573006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171325998
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