Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species. Although the antioxidant ascorbic acid (AA) or vitamin C does not penetrate the blood–brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport. W...

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Autori principali: Huang, Judy, Agus, David B., Winfree, Christopher J., Kiss, Szilard, Mack, William J., McTaggart, Ryan A., Choudhri, Tanvir F., Kim, Louis J, Mocco, J, Pinsky, David J., Fox, William D., Israel, Robert J., Boyd, Thomas A., Golde, David W., Connolly, E. Sander
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC58796/
https://ncbi.nlm.nih.gov/pubmed/11573006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171325998
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