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Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral infarct volumes in mice following transient middle cerebral artery occlusion, even when given 3 hours a...
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150939/ https://ncbi.nlm.nih.gov/pubmed/11956240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI10649 |
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