Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3-kinase, p85α and its splice variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 improves insulin signaling and glucose homeostasis in normal mice and mic...

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Main Authors: Mauvais-Jarvis, Franck, Ueki, Kohjiro, Fruman, David A., Hirshman, Michael F., Sakamoto, Kei, Goodyear, Laurie J., Iannacone, Matteo, Accili, Domenico, Cantley, Lewis C., Kahn, C. Ronald
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150818/
https://ncbi.nlm.nih.gov/pubmed/11781359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13305
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