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Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

Hypoxia, reoxygenation, and the tyrosine phosphatase inhibitor pervanadate activate the transcription factor NF-κB, involving phosphorylation of its inhibitor IκB-α on tyrosine 42. This modification does not lead to degradation of IκB by the proteasome/ubiquitin pathway, as is seen on stimulation of...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Béraud, Christophe, Henzel, William J., Baeuerle, Patrick A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15153/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9892650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.2.429
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