NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression

Summary: While ligand-activated glucocorticoid receptor (GR) binds DNA to activate transcription, glucocorticoids, including budesonide, reduce inflammatory gene expression, yet recruit GR to many such gene loci. In epithelial cells, the inflammatory cytokine, interleukin-1β (IL1B), activates nuclea...

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Bibliografische Detailangaben

Hauptverfasser:	Mahmoud M. Mostafa, Amandah Necker-Brown, Alex Gao, Andrew J. Thorne, Akanksha Bansal, Lucy Swift, Annika M. Maj, Sarah K. Sasse, Pina Colarusso, Anthony N. Gerber, Robert Newton
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-12-01
Schriftenreihe:	iScience
Schlagworte:	Genomics Gene network Molecular mechanism of gene regulation
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004225024678
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