Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB.

Interferon regulatory factors (IRFs) play key roles during viral and bacterial infections. However, their regulation by inflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor (TNF) α, remains underexplored. As airway epithelial cells (AECs) modulate lung inflammation, IRF ex...

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Autores principales:	Amandah Necker-Brown, Mahmoud M Mostafa, Andrei Georgescu, Andrew J Thorne, Priyanka Chandramohan, Cora Kooi, Keerthana Kalyanaraman, Alex Gao, Akanksha Bansal, Sarah K Sasse, Anthony N Gerber, Richard Leigh, Robert Newton
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2025-01-01
Colección:	PLoS ONE
Acceso en línea:	https://doi.org/10.1371/journal.pone.0329244
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