Transcription-Dependent Degradation of Topoisomerase I-DNA Covalent Complexes

Topoisomerase I (Top I)-DNA covalent complexes represent a unique type of DNA lesion whose repair and processing remain unclear. In this study, we show that Top I-DNA covalent complexes transiently arrest RNA transcription in normal nontransformed cells. Arrest of RNA transcription is coupled to act...

Full description

Saved in:
Bibliographic Details
Main Authors: Desai, Shyamal D., Zhang, Hui, Rodriguez-Bauman, Alexandra, Yang, Jin-Ming, Wu, Xiaohua, Gounder, Murugesan K., Rubin, Eric H., Liu, Leroy F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150741/
https://ncbi.nlm.nih.gov/pubmed/12640119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2341-2350.2003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items