Transcription-Dependent Degradation of Topoisomerase I-DNA Covalent Complexes

Topoisomerase I (Top I)-DNA covalent complexes represent a unique type of DNA lesion whose repair and processing remain unclear. In this study, we show that Top I-DNA covalent complexes transiently arrest RNA transcription in normal nontransformed cells. Arrest of RNA transcription is coupled to act...

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Autores principales: Desai, Shyamal D., Zhang, Hui, Rodriguez-Bauman, Alexandra, Yang, Jin-Ming, Wu, Xiaohua, Gounder, Murugesan K., Rubin, Eric H., Liu, Leroy F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Transcriptional Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC150741/
https://ncbi.nlm.nih.gov/pubmed/12640119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2341-2350.2003
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