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SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Ubiquitin/26S proteasome-dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1-mediated DNA damage. In the current study, we show that treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent mo...

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書目詳細資料
Main Authors: Mao, Yong, Sun, Mei, Desai, Shyamal D., Liu, Leroy F.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC18143/
https://ncbi.nlm.nih.gov/pubmed/10759568
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