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SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Ubiquitin/26S proteasome-dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1-mediated DNA damage. In the current study, we show that treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent mo...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mao, Yong, Sun, Mei, Desai, Shyamal D., Liu, Leroy F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18143/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10759568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.080536597
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