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The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway
It has been proposed that the topoisomerase II (TOP2)β–DNA covalent complex arrests transcription and triggers 26S proteasome-mediated degradation of TOP2β. It is unclear whether the initial trigger for proteasomal degradation is due to DNA damage or transcriptional arrest. In the current study we s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152276/ https://ncbi.nlm.nih.gov/pubmed/12629207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0736401100 |
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