The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway

It has been proposed that the topoisomerase II (TOP2)β–DNA covalent complex arrests transcription and triggers 26S proteasome-mediated degradation of TOP2β. It is unclear whether the initial trigger for proteasomal degradation is due to DNA damage or transcriptional arrest. In the current study we s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xiao, Hai, Mao, Yong, Desai, Shyamal D., Zhou, Nai, Ting, Chun-Yuan, Hwang, Jaulang, Liu, Leroy F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2003
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC152276/
https://ncbi.nlm.nih.gov/pubmed/12629207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0736401100
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