The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway

It has been proposed that the topoisomerase II (TOP2)β–DNA covalent complex arrests transcription and triggers 26S proteasome-mediated degradation of TOP2β. It is unclear whether the initial trigger for proteasomal degradation is due to DNA damage or transcriptional arrest. In the current study we s...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Xiao, Hai, Mao, Yong, Desai, Shyamal D., Zhou, Nai, Ting, Chun-Yuan, Hwang, Jaulang, Liu, Leroy F.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2003
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12629207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0736401100
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