The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway

It has been proposed that the topoisomerase II (TOP2)β–DNA covalent complex arrests transcription and triggers 26S proteasome-mediated degradation of TOP2β. It is unclear whether the initial trigger for proteasomal degradation is due to DNA damage or transcriptional arrest. In the current study we s...

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Bibliographic Details
Main Authors: Xiao, Hai, Mao, Yong, Desai, Shyamal D., Zhou, Nai, Ting, Chun-Yuan, Hwang, Jaulang, Liu, Leroy F.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC152276/
https://ncbi.nlm.nih.gov/pubmed/12629207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0736401100
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