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Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

IL-13 potently stimulates eosinophilic and lymphocytic inflammation and alveolar remodeling in the lung, effects that depend on the induction of various matrix metalloproteinases (MMPs). Here, we compared the remodeling and inflammatory effects of an IL-13 transgene in lungs of wild-type, MMP-9–defi...

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Udgivet i:J Clin Invest
Principais autores: Lanone, Sophie, Zheng, Tao, Zhu, Zhou, Liu, Wei, Lee, Chun Geun, Ma, Bing, Chen, Qingsheng, Homer, Robert J., Wang, Jingming, Rabach, Lesley A., Rabach, Morgan E., Shipley, J. Michael, Shapiro, Steven D., Senior, Robert M., Elias, Jack A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150413/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189240/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14136
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