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Identifying Kinetic Barriers to Mechanical Unfolding of the T. thermophila Ribozyme
Mechanical unfolding trajectories for single molecules of the Tetrahymena thermophila ribozyme display eight intermediates corresponding to discrete kinetic barriers that oppose mechanical unfolding with lifetimes of seconds and rupture forces between 10 and 30 piconewtons. Barriers are magnesium de...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1503549/ https://ncbi.nlm.nih.gov/pubmed/12649482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1081338 |
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