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NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork

RNA helicases regulate virtually all RNA-dependent cellular processes. Although much is known about helicase structures, very little is known about how they deal with barriers in RNA and the factors that affect their processivity. The hepatitis C virus encodes NS3, an RNA helicase that is essential...

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Detalhes bibliográficos
Main Authors: Cheng, Wei, Dumont, Sophie, Tinoco, Ignacio, Bustamante, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955789/
https://ncbi.nlm.nih.gov/pubmed/17709749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702315104
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