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NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork

RNA helicases regulate virtually all RNA-dependent cellular processes. Although much is known about helicase structures, very little is known about how they deal with barriers in RNA and the factors that affect their processivity. The hepatitis C virus encodes NS3, an RNA helicase that is essential...

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Autores principales: Cheng, Wei, Dumont, Sophie, Tinoco, Ignacio, Bustamante, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955789/
https://ncbi.nlm.nih.gov/pubmed/17709749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702315104
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