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ICP0 and the U(S)3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression

SK-N-SH cells exposed to low ratios of ICP0-null (ΔICP0) mutants of herpes simplex virus per cell express the viral α proteins, but the progression to β and γ gene expression does not ensue. In these restrictive cells, post-α gene expression can be induced after exposure of the infected cells to sod...

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Detalhes bibliográficos
Principais autores: Poon, Alice P. W., Gu, Haidong, Roizman, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502567/
https://ncbi.nlm.nih.gov/pubmed/16785443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604142103
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