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During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins

ICP0 is a multifunctional herpes simplex virus protein known primarily as a promiscuous transactivator. In the course of productive infection, it is localized during the first 5–7 h in the nucleus and later in the cytoplasm. In the nucleus, its primary activities are to suppress the silencing of vir...

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Bibliografiske detaljer
Main Authors: Gu, Haidong, Poon, Alice P., Roizman, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776466/
https://ncbi.nlm.nih.gov/pubmed/19850872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910920106
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