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Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST–REST complex

A preeminent phenotype of the infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) is that it acts as a promiscuous transactivator. In most cell lines exposed to ΔICP0 mutant virus at low ratios of virus per cell infection, α genes are expressed but the transition to β and γ gene express...

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Autori principali: Gu, Haidong, Roizman, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040395/
https://ncbi.nlm.nih.gov/pubmed/17939992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707266104
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