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Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus

In nonneuronal cells, herpes simplex virus 1 overcomes host defenses, replicates, and ultimately kills the infected cell. Among the host defenses suppressed by the virus is a repressor complex whose key components are histone deacetylase (HDAC) 1 or 2, RE-1 silencing transcription factor (REST), cor...

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Bibliografiske detaljer
Main Authors: Du, Te, Zhou, Guoying, Khan, Shaniya, Gu, Haidong, Roizman, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936609/
https://ncbi.nlm.nih.gov/pubmed/20798038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010741107
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