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Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal
Apoptosis-inducing factor (AIF) is an evolutionarily conserved, ubiquitously expressed flavoprotein with NADH oxidase activity that is normally confined to mitochondria. In mammalian cells, AIF is released from mitochondria in response to apoptotic stimuli and translocates to the nucleus where it is...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502554/ https://ncbi.nlm.nih.gov/pubmed/16788063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603950103 |
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