Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal

Apoptosis-inducing factor (AIF) is an evolutionarily conserved, ubiquitously expressed flavoprotein with NADH oxidase activity that is normally confined to mitochondria. In mammalian cells, AIF is released from mitochondria in response to apoptotic stimuli and translocates to the nucleus where it is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brown, Doris, Yu, Benjamin D., Joza, Nicholas, Bénit, Paule, Meneses, Juanito, Firpo, Meri, Rustin, Pierre, Penninger, Josef M., Martin, Gail R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502554/
https://ncbi.nlm.nih.gov/pubmed/16788063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603950103
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