Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency

Mice with the hypomorphic AIF-Harlequin mutation exhibit a highly heterogeneous mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral pathology that resembles that found in patients with AIF loss-of-function mutations. Here we describe that the antidiabetic drug piogl...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Bénit, Paule, Pelhaître, Alice, Saunier, Elise, Bortoli, Sylvie, Coulibaly, Assetou, Rak, Malgorzata, Schiff, Manuel, Kroemer, Guido, Zeviani, Massimo, Rustin, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360583/
https://ncbi.nlm.nih.gov/pubmed/28229909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.02.013
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