Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein implicated in programmed cell death, plays a role in mitochondrial respiration. However, the in vivo consequen...

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Detalhes bibliográficos
Main Authors: Joza, Nicholas, Oudit, Gavin Y., Brown, Doris, Bénit, Paule, Kassiri, Zamaneh, Vahsen, Nicola, Benoit, Loralyn, Patel, Mikin M., Nowikovsky, Karin, Vassault, Anne, Backx, Peter H., Wada, Teiji, Kroemer, Guido, Rustin, Pierre, Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291246/
https://ncbi.nlm.nih.gov/pubmed/16287843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10261-10272.2005
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