Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein implicated in programmed cell death, plays a role in mitochondrial respiration. However, the in vivo consequen...

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Hlavní autoři: Joza, Nicholas, Oudit, Gavin Y., Brown, Doris, Bénit, Paule, Kassiri, Zamaneh, Vahsen, Nicola, Benoit, Loralyn, Patel, Mikin M., Nowikovsky, Karin, Vassault, Anne, Backx, Peter H., Wada, Teiji, Kroemer, Guido, Rustin, Pierre, Penninger, Josef M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291246/
https://ncbi.nlm.nih.gov/pubmed/16287843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10261-10272.2005
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