Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis

Angiotensin-converting enzyme-2 (ACE2), a membrane-bound carboxymonopeptidase highly expressed in the kidney, functions as a negative regulator of the renin-angiotensin system. Here we report early accumulation of fibrillar collagen in the glomerular mesangium of male ACE2 mutant (ACE2(−/y)) mice fo...

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Detalhes bibliográficos
Main Authors: Oudit, Gavin Y., Herzenberg, Andrew M., Kassiri, Zamaneh, Wong, Denise, Reich, Heather, Khokha, Rama, Crackower, Michael A., Backx, Peter H., Penninger, Josef M., Scholey, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606622/
https://ncbi.nlm.nih.gov/pubmed/16723697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051091
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