Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein implicated in programmed cell death, plays a role in mitochondrial respiration. However, the in vivo consequen...

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Bibliographische Detailangaben
Hauptverfasser: Joza, Nicholas, Oudit, Gavin Y., Brown, Doris, Bénit, Paule, Kassiri, Zamaneh, Vahsen, Nicola, Benoit, Loralyn, Patel, Mikin M., Nowikovsky, Karin, Vassault, Anne, Backx, Peter H., Wada, Teiji, Kroemer, Guido, Rustin, Pierre, Penninger, Josef M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291246/
https://ncbi.nlm.nih.gov/pubmed/16287843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10261-10272.2005
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