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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site
Herein, we report the identification of a unique HIV-1 integrase (IN) inhibitor-binding site using photoaffinity labeling and mass spectrometric analysis. We chemically incorporated a photo-activatable benzophenone moiety into a series of coumarin-containing IN inhibitors. A representative of this s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502509/ https://ncbi.nlm.nih.gov/pubmed/16785440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511254103 |
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