Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor

The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-Å resolution at two pH values, with and without Mn(2+) cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activ...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lubkowski, Jacek, Yang, Fan, Alexandratos, Jerry, Wlodawer, Alexander, Zhao, He, Burke, Terrence R., Neamati, Nouri, Pommier, Yves, Merkel, George, Skalka, Anna Marie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560188/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.4831
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