Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor

The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-Å resolution at two pH values, with and without Mn(2+) cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activ...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lubkowski, Jacek, Yang, Fan, Alexandratos, Jerry, Wlodawer, Alexander, Zhao, He, Burke, Terrence R., Neamati, Nouri, Pommier, Yves, Merkel, George, Skalka, Anna Marie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1998
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC20173/
https://ncbi.nlm.nih.gov/pubmed/9560188
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