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Effect of HIV integrase inhibitors on the RAG1/2 recombinase
Assembly of functional Ig and T cell receptor genes by V(D)J recombination depends on site-specific cleavage of chromosomal DNA by the RAG1/2 recombinase. As RAG1/2 action has mechanistic similarities to DNA transposases and integrases such as HIV-1 integrase, we sought to determine how integrase in...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117527/ https://ncbi.nlm.nih.gov/pubmed/11756686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012610699 |
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