Effect of HIV integrase inhibitors on the RAG1/2 recombinase

Assembly of functional Ig and T cell receptor genes by V(D)J recombination depends on site-specific cleavage of chromosomal DNA by the RAG1/2 recombinase. As RAG1/2 action has mechanistic similarities to DNA transposases and integrases such as HIV-1 integrase, we sought to determine how integrase in...

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Bibliographic Details
Main Authors: Melek, Meni, Jones, Jessica M., O'Dea, Mary H., Pais, Godwin, Burke, Terrence R., Pommier, Yves, Neamati, Nouri, Gellert, Martin
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC117527/
https://ncbi.nlm.nih.gov/pubmed/11756686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012610699
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